Kwan A L, Meiners A P, van Grootheest A C, Lekkerkerker J F
College ter beoordeling van geneesmiddelen, Postbus 16229, 2500 BE Den Haag.
Ned Tijdschr Geneeskd. 2001 Feb 10;145(6):277-8.
Bupropion is a new aid in smoking cessation. Since marketing of this product in the Netherlands (from December 1999 on), 7 cases of (possible) convulsions have been reported. In 3 cases there was a contraindication in the form of a history of epilepsy. The four other cases concerned tonic-clonic epileptic seizures in patients with no history of epilepsy and no combination with other medication. In view of the seriousness of this, already known, side effect of bupropion, physicians ought to be sensitive to situations with increased risk of this side effect. In addition it is advised to explain to the patient the proper use of bupropion, which is not comparable to nicotine chewing gum and should be swallowed whole due to the slow release properties of the tablet.
安非他酮是戒烟的一种新辅助药物。自该产品在荷兰上市（从1999年12月起）以来，已报告了7例（可能的）惊厥病例。其中3例有癫痫病史这一禁忌情况。另外4例涉及无癫痫病史且未同时服用其他药物的患者发生强直阵挛性癫痫发作。鉴于安非他酮这种已知副作用的严重性，医生应对此副作用风险增加的情况保持警惕。此外，建议向患者解释安非他酮的正确用法，它与尼古丁口香糖不同，由于片剂的缓释特性，应整片吞服。
