Wang Q, Wang H, Zhang H
Department of Neurology, 461 Hospital of PLA, Changchun 130021, China.
Zhonghua Yi Xue Za Zhi. 2000 Dec;80(12):947-9.
To investigate an animal model of axonal form Guillain-Barre syndrome (GBS).
A strain of Campylobacter jejuni (Cj PENO: 19) from stools of a patient with axonal form GBS was isolated. After the lypopolysaccharides (LPS) were extracted from the strain, they were inoculated into 26 rabbits, 10 micrograms per week.
Three rabbits showed paralysis, with an incidence rate of 11.54%. For the three rabbits, LPS was inoculated two, three and three times, respectively. Pathological examination showed serious axonal degeneration in the sciatic nerve. The electrophysiological features showed motor axon damage.
The results suggested the presence of an axonal form GBS. LPS in Cj could play an important role in causing axonal form GBS.
研究轴索性吉兰-巴雷综合征（GBS）的动物模型。
从一名轴索性GBS患者的粪便中分离出一株空肠弯曲菌（Cj PENO: 19）。从该菌株中提取脂多糖（LPS）后，将其接种到26只兔子体内，每周接种10微克。
3只兔子出现麻痹，发病率为11.54%。对于这3只兔子，LPS分别接种了2次、3次和3次。病理检查显示坐骨神经有严重的轴突变性。电生理特征显示运动轴突损伤。
结果提示存在轴索性GBS。空肠弯曲菌中的LPS在导致轴索性GBS中可能起重要作用。
