三个巴西族群中两个短串联重复序列位点（CD4和F13A1）的多样性

Diversity of two short tandem repeat loci (CD4 and F13A1) in three Brazilian ethnic groups.

作者信息

Bogdawa H M, Hutz M H, Salzano F M, Weimer T A

机构信息

Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

出版信息

Hum Biol. 2000 Dec;72(6):1045-53.

PMID:11236860

Abstract

Two microsatellites (CD4 and F13A1) were investigated in seven Brazilian populations: one group each of European- and African-derived subjects from Porto Alegre, southern Brazil, and five Amerindian tribes (three Tupi-Mondé speaking [Gavião, Surui, and Zoró], one Macro-Gê [Xavante], and one Carib [Wai-Wai]). For both markers, neo-Brazilians presented with a high diversity, but Amerindians showed a low level of variability. Genotype frequency distributions were heterogeneous among populations, the only exception being similar CD4 frequencies in Afro- and Euro-Brazilians. Gene diversity analysis revealed that most of the total variation is due to intrapopulational diversity in all populations. Because of the high information content of these markers in Afro- and Euro-Brazilians, these systems are most appropriate for forensic analyses. The comparison among Brazilian and other world populations revealed high similarity among populations of the same ethnic group, indicating a high discriminative power for these markers.

摘要

在七个巴西人群中对两个微卫星（CD4和F13A1）进行了研究：一组是来自巴西南部阿雷格里港的欧洲裔和非洲裔受试者，以及五个美洲印第安部落（三个讲图皮-蒙代语的部落[加维昂、苏鲁伊和佐罗]、一个大盖语部落[沙万特]和一个加勒比语部落[瓦伊-瓦伊]）。对于这两个标记，新巴西人表现出高度的多样性，但美洲印第安人显示出低水平的变异性。基因型频率分布在各人群之间是异质的，唯一的例外是非洲裔和欧洲裔巴西人在CD4频率上相似。基因多样性分析表明，所有人群中大部分总变异是由于群体内多样性。由于这些标记在非洲裔和欧洲裔巴西人中具有高信息含量，这些系统最适合法医分析。巴西人群与世界其他人群之间的比较显示，同一族群的人群之间具有高度相似性，表明这些标记具有高鉴别力。