Li W H, Gu Z, Wang H, Nekrutenko A
Ecology and Evolution, University of Chicago, Illinois 60637, USA.
Nature. 2001 Feb 15;409(6822):847-9. doi: 10.1038/35057039.
The completion of the human genome will greatly accelerate the development of a new branch of science--evolutionary genomics. We can now directly address important questions about the evolutionary history of human genes and their regulatory sequences. Computational analyses of the human genome will reveal the number of genes and repetitive elements, the extent of gene duplication and compositional heterogeneity in the human genome, and the extent of domain shuffling and domain sharing among proteins. Here we present some first glimpses of these features.
人类基因组测序的完成将极大地加速一门新科学分支——进化基因组学的发展。现在我们能够直接探讨有关人类基因及其调控序列进化史的重要问题。对人类基因组的计算分析将揭示基因和重复元件的数量、人类基因组中基因复制和组成异质性的程度，以及蛋白质之间结构域改组和结构域共享的程度。在此，我们首次展示这些特征。
