血浆中脂质氢过氧化物的归宿

Fate of lipid hydroperoxides in blood plasma.

作者信息

Yamamoto Y

机构信息

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Japan.

出版信息

Free Radic Res. 2000 Dec;33(6):795-800. doi: 10.1080/10715760000301311.

DOI:10.1080/10715760000301311

PMID:11237101

Abstract

Cholesteryl ester hydroperoxide (CE-OOH) and phosphatidylcholine hydroperoxide (PC-OOH) are the major primary oxidation products of lipoproteins. CE-OOH is present in human and rat plasmas while PC-OOH is undetectable. This is likely due to the enzymatic (plasma glutathione peroxidase) and the nonenzymatic (apolipoproteins A and B-100) reducing activities of PC-OOH in plasma, and to the enzymatic conversion of PC-OOH to CE-OOH by lecithin:cholesterol acyltransferase in high density lipoproteins. The regioisomeric distribution of CE-O(O)H in human plasma indicates that free radical-mediated chain oxidation is an ongoing process, even in healthy young individuals.

摘要

胆固醇酯氢过氧化物（CE-OOH）和磷脂酰胆碱氢过氧化物（PC-OOH）是脂蛋白的主要初级氧化产物。CE-OOH存在于人和大鼠血浆中，而PC-OOH无法检测到。这可能是由于血浆中PC-OOH的酶促（血浆谷胱甘肽过氧化物酶）和非酶促（载脂蛋白A和B-100）还原活性，以及高密度脂蛋白中卵磷脂：胆固醇酰基转移酶将PC-OOH酶促转化为CE-OOH。人血浆中CE-O(O)H的区域异构体分布表明，即使在健康的年轻人中，自由基介导的链式氧化也是一个持续进行的过程。