Otero Areán C, Barceló F, Fenoglio I, Fubini B, Llabrés i Xamena F X, Tomatis M
Departamento de Química, Universidad de las Islas Baleares, Palma de Mallorca, Spain.
J Inorg Biochem. 2001 Jan 15;83(2-3):211-6. doi: 10.1016/s0162-0134(00)00191-4.
The amphibole minerals amosite and crocidolite were subjected to calcination and to hydrothermal treatment in order to study the effect of these heat treatments on the ability of the minerals to trigger formation of free radicals, which is known to be a main factor causing asbestosis and other asbestos-induced diseases. Free radical activity of the natural and heat treated minerals was studied by using supercoiled DNA (pUC18 plasmid) as a target molecule, and also by means of EPR spectroscopy. It was shown that after calcination of the natural minerals at 1073 K their free radical activity was strongly decreased These results, which may have relevant consequences for asbestos technology, were correlated with concomitant alteration of the structure and surface chemistry of the minerals during calcination.
对铁石棉和青石棉这两种闪石矿物进行了煅烧和水热处理，以研究这些热处理对矿物引发自由基形成能力的影响，自由基形成是导致石棉沉着病和其他石棉诱发疾病的主要因素。通过使用超螺旋DNA（pUC18质粒）作为靶分子，并借助电子顺磁共振光谱法，研究了天然矿物和热处理矿物的自由基活性。结果表明，天然矿物在1073K煅烧后，其自由基活性大幅降低。这些结果可能对石棉技术产生相关影响，它们与煅烧过程中矿物结构和表面化学的相应变化相关。
