Agostoni C, Scaglioni S, Bonvissuto M, Bruzzese M G, Giovannini M, Riva E
Department of Pediatrics, San Paolo Hospital, Milan, 20142, Italy.
Prostaglandins Leukot Essent Fatty Acids. 2001 Feb;64(2):111-5. doi: 10.1054/plef.2001.0249.
Hyperphenylalaninemic (HPA) children display low levels of long-chain polyunsaturated fatty acids (LCPUFA), particularly docosahexaenoic acid (DHA), in circulating lipids and erythrocytes. We have investigated the effects on the blood fatty acid status and lipid picture of a balanced supplementation with LCPUFA in HPA children through a double-blind, placebo-controlled trial. A total of 20 well-controlled HPA, school-age children were randomized to receive through a 12-month trial fat capsules supplying either 26% fatty acid as LCPUFA (including 4.6%gamma -linolenic acid, 7.4% arachidonic acid, AA, 5.5% eicosapentaenoic acid and 8% DHA) or placebo (olive oil). The study supplementation was administered in order to provide 0.3-0.5% of the individual daily energy requirements as LCPUFA. Reference data were obtained from healthy children of comparable age. Among HPA children (whose DHA status was poor at baseline), those supplemented with LCPUFA showed an increase of around 100% in the baseline DHA levels in plasma phospholipids and erythrocytes. No changes of AA levels were observed. Blood lipid levels did not significantly change. A balanced supplementation with LCPUFA in treated HPA children may improve the DHA status without adversely affecting the AA status.
高苯丙氨酸血症（HPA）儿童循环脂质和红细胞中的长链多不饱和脂肪酸（LCPUFA）水平较低，尤其是二十二碳六烯酸（DHA）。我们通过一项双盲、安慰剂对照试验，研究了在HPA儿童中均衡补充LCPUFA对血液脂肪酸状态和血脂情况的影响。共有20名病情得到良好控制的学龄期HPA儿童被随机分组，在为期12个月的试验中接受脂肪胶囊，其中一组胶囊提供的脂肪酸中有26%为LCPUFA（包括4.6%的γ-亚麻酸、7.4%的花生四烯酸、5.5%的二十碳五烯酸和8%的DHA），另一组接受安慰剂（橄榄油）。进行该研究补充剂的给药，以便提供占个体每日能量需求0.3 - 0.5%的LCPUFA。参考数据来自年龄相仿的健康儿童。在HPA儿童（其基线时DHA状态较差）中，补充LCPUFA的儿童血浆磷脂和红细胞中的DHA水平在基线时提高了约100%。未观察到花生四烯酸水平的变化。血脂水平未发生显著变化。在接受治疗的HPA儿童中均衡补充LCPUFA可能会改善DHA状态，而不会对花生四烯酸状态产生不利影响。
