Okayama A, Stuver S, Iga M, Okamoto M, Mueller N, Matsuoka M, Yamaguchi K, Tachibana N, Tsubouchi H
Department of Internal Medicine II, Miyazaki Medical College, Kiyotake, Miyazaki 8891601, Japan.
J Infect Dis. 2001 Apr 1;183(7):1031-7. doi: 10.1086/319282. Epub 2001 Feb 28.
Twenty-three human T lymphotropic virus type I (HTLV-I) seroconverters were identified among 1120 HTLV-I-seronegative adults followed up for 11 years in an area of Japan endemic for HTLV-I. The geometric mean titer of anti-HTLV-I was 1:453 in the first year after seroconversion; the titer of each subject did not change significantly during 2-10 years of follow-up. HTLV-I proviral DNA load was quantified in 15 seroconverters, and a broad range of levels was observed-from <10 to >1000 copies/10(5) peripheral blood mononuclear cells. However, there was no obvious change in HTLV-I proviral DNA load over several years within individual subjects. Therefore, both proviral DNA load and humoral response in adult HTLV-I seroconverters were shown to stabilize within a few years after initial infection. In addition, 1 subject tested positive for HTLV-I proviral DNA before antibody seroconversion, which suggests the existence of a window period in community-acquired infection.
在日本HTLV-I流行地区，对1120名HTLV-I血清阴性成年人进行了11年随访，共发现23例HTLV-I血清转化者。血清转化后第一年抗HTLV-I的几何平均滴度为1:453；在2至10年的随访期间，每个受试者的滴度没有显著变化。对15名血清转化者的HTLV-I前病毒DNA载量进行了定量，观察到其水平范围很广——从<10到>1000拷贝/10(5)外周血单个核细胞。然而，在个体受试者中，几年内HTLV-I前病毒DNA载量没有明显变化。因此，成人HTLV-I血清转化者的前病毒DNA载量和体液反应在初次感染后的几年内均趋于稳定。此外，1名受试者在抗体血清转化前HTLV-I前病毒DNA检测呈阳性，这表明在社区获得性感染中存在窗口期。
