Lebedev A A, Kantariia V A
Kardiologiia. 1975 Feb;15(2):52-7.
The effects of furosemide, hydrochlorthiazide, triamteren and mannitol on the intratubular potential, electric resistance of the wall of the proximal and distal renal tubule and also changes in the magnitude of the short-circuited current that give an idea as to the tubular transport of sodium in the proximal section of nephron were explored electrophysiologically on a renal nephron of the rat. Furosemide and hydrochlorthiazide depressed the magnitude of the short-circuited current in the proximal end of nephron and raised the transtubular potential. Hydrochlorthiazide also tended to increase the electric resistance of the renal tubule wall. Triamteren forced down the potential in the proximal end of nephron, as well as the magnitude of the short-circuited current, but did not change the tubular wall resistance. Mannitol drastically reduced the tubular wall resistance and the intratubular potential, without affecting the short-circuited current. A classification of diuretics by the mode of their action on the electric parameters of the nephron is given.
通过对大鼠肾单位进行电生理学研究，探讨了呋塞米、氢氯噻嗪、氨苯蝶啶和甘露醇对肾小管内电位、近端和远端肾小管壁电阻以及短路电流大小变化的影响，后者可反映肾单位近端段钠的肾小管转运情况。呋塞米和氢氯噻嗪降低了肾单位近端短路电流的大小，并提高了跨管电位。氢氯噻嗪还倾向于增加肾小管壁电阻。氨苯蝶啶降低了肾单位近端的电位以及短路电流的大小，但未改变肾小管壁电阻。甘露醇显著降低了肾小管壁电阻和管内电位，而不影响短路电流。给出了根据利尿剂对肾单位电参数作用方式的分类。
