Pitts R F, MacLeod M B
Kidney Int. 1975 Mar;7(3):130-6. doi: 10.1038/ki.1975.20.
The CO2 produced in the metabolism of blood glucose by the kidney has been measured by the i.v. infusion 14C-UL-D-glucose as a tracer. A small fraction of circulating 14C-glucose is converted to labeled lactate in extrarenal tissues, returned to, extracted by and metabolized to CO2 in the kidney. Correcting the apparent 14CO2 produced in the kidney from glucose for the 14CO2 produced from lactate yields that produced directly from glucose. Differences in production of CO2 from glucose in chronic metabolic acidosis and alkalosis are small and probably are not significant. If so, somewhat less than one-quarter of the total metabolism of the intact functioning kidney is supported by blood glucose. These measurements have been made at normal endogenous blood concentrations of glucose.
通过静脉输注14C-U-L-葡萄糖作为示踪剂，测量了肾脏中血糖代谢产生的二氧化碳。循环中的一小部分14C-葡萄糖在肾外组织中转化为标记的乳酸，返回肾脏，被肾脏摄取并代谢为二氧化碳。从乳酸产生的14CO2中校正肾脏中由葡萄糖产生的表观14CO2，得出直接由葡萄糖产生的14CO2。慢性代谢性酸中毒和碱中毒时葡萄糖产生二氧化碳的差异很小，可能不显著。如果是这样，完整功能肾脏的总代谢中，由血糖支持的部分略少于四分之一。这些测量是在正常内源性血糖浓度下进行的。
