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Activity and mRNA abundance of Delta-5 and Delta-6 fatty acid desaturases in two human cell lines.

作者信息

de Antueno R J, Allen S J, Ponton A, Winther M D

机构信息

QuantaNova Canada Ltd., P.O. Box 818, B4N 4H8, Kentville, N.S., Canada.

出版信息

FEBS Lett. 2001 Mar 2;491(3):247-51. doi: 10.1016/s0014-5793(01)02209-8.

DOI:10.1016/s0014-5793(01)02209-8
PMID:11240136
Abstract

We analyzed fatty acid biosynthesis in Chang and ZR-75-1 cells. Both cell lines could desaturate and further elongate substrates for Delta-5 desaturase. ZR-75-1 but not Chang cells showed Delta-6 desaturation of 18:2n-6, 18:3n-3, 24:4n-6 and 24:5n-3. In both cell lines, the mRNA abundance can be related to Delta-5 or Delta-6 fatty acid desaturase activities. These results suggest that desaturase genes could have, at least in part, independent control mechanisms and that Delta-6 desaturase impairment is not specific to any particular step of the fatty acid metabolic pathways, which may diminish the rationale for the existence of at least two distinct enzymes.

摘要

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Biochem J. 2002 May 15;364(Pt 1):49-55. doi: 10.1042/bj3640049.