Perkel D J, Farries M A
Department of Neuroscience, 215 Stemmler Hall, University of Pennsylvania, Philadelphia, PA 19104-6074, USA.
Curr Opin Neurobiol. 2000 Dec;10(6):725-31. doi: 10.1016/s0959-4388(00)00156-2.
Recently, two quite different approaches exemplifying 'bottom-up' and 'top-down' philosophies have shed new light on basal ganglia function. In vitro work using organotypic co-cultures has implicated the subthalamic nucleus (STN) and the external segment of the globus pallidus (GP(e)) as pacemakers for low-frequency bursting that is reminiscent of the activity produced in Parkinsonian tremor. A circuit essential for avian song learning has been identified as part of the basal ganglia with surprisingly well conserved cellular details; investigation of this system may help to address general issues of basal ganglia function.
最近，两种截然不同的、分别体现“自下而上”和“自上而下”理念的方法，为基底神经节的功能带来了新的认识。利用器官型共培养的体外研究表明，丘脑底核（STN）和苍白球外侧部（GP(e)）是低频爆发的起搏器，这让人联想到帕金森震颤中产生的活动。一种对鸟类歌声学习至关重要的神经回路已被确定为基底神经节的一部分，其细胞细节惊人地保守；对该系统的研究可能有助于解决基底神经节功能的一般问题。
