Raut V, Cullen J, Hughes D
Department of ENT, Altnagelvin Area Hospital, Glenshane Road, BT47 6SB, Londonderry, UK.
Auris Nasus Larynx. 2001 Apr;28(2):185-8. doi: 10.1016/s0385-8146(00)00106-1.
Giant lymph node hyperplasia (GLNH) or Castleman's disease is a rare pathological entity commonly presenting as a solitary mediastinal tumour (unifocal variant), although other anatomical sites have been reported including the head and neck, abdomen and axilla. Though the head and neck is the second commonest site for this lesion, only 60 cases [1,2] have been reported in the literature. Pre-operative diagnosis of the unifocal variant can be difficult as routine investigations carried out in the clinic setting are often inconclusive. A multicentric form of this disease with a poorer prognosis in comparison to the unifocal lesion has been described by Gaba et al. in 1978 [3]. We present a case of an unusually large, slow growing, asymptomatic, unifocal variant of this tumour restricted to the neck which underwent successful surgical excision. A review of the literature, histopathological characteristics and differential diagnosis is also presented.
巨大淋巴结增生症（GLNH）或卡斯尔曼病是一种罕见的病理实体，通常表现为孤立性纵隔肿瘤（单灶性变体），不过也有报道称其可发生于其他解剖部位，包括头颈部、腹部和腋窝。虽然头颈部是该病变的第二常见部位，但文献中仅报道了60例[1,2]。单灶性变体的术前诊断可能具有挑战性，因为临床常规检查往往无法得出明确结论。1978年，加巴等人描述了这种疾病的多中心形式，与单灶性病变相比，其预后较差[3]。我们报告了一例局限于颈部的这种肿瘤的异常巨大、生长缓慢、无症状的单灶性变体病例，该病例成功接受了手术切除。本文还对相关文献、组织病理学特征及鉴别诊断进行了综述。
