Riahi I, Mokni M, Haouet S, Cherif F, El Euch D, Azaiz M I, Zitouna M M, Ben Osman-Dhahri A
Service de Dermatologie, Hôpital de La Rabta, Bab Saadoun, Tunis, Tunisie.
Ann Med Interne (Paris). 2001 Feb;152(1):3-9.
We report a retrospective study of 15 cases of pyoderma gangrenosum. The male/female ratio was 2, average age 40 years (range: 2-48 years). The typical ulcerous form was observed in 11 patients, whereas bullous pyodrma gangrenosum was noted in 2 patients and the granulomatous superficial form in 2 others. The leg was the most frequent localization. It was often associated with another skin localization. Two patients had neutrophilic pulmonary involvement which was concomitant to the skin ulcers. Association with internal disease was found in 8 patients. Histology showed vasculitis in 11 patients. In 9 of them, leukocytoclastic vasculitis was observed. Prednisone and clofazimine were the most frequently prescribed drugs. Th rate of recurrence of pyoderma gangrenosum was 46% independently of treatment. Occurrence of neutrophilic pneumopathy was rapidly fatal in two of our patients
我们报告了一项对15例坏疽性脓皮病的回顾性研究。男女比例为2，平均年龄40岁（范围：2至48岁）。11例患者观察到典型的溃疡型，2例患者出现大疱性坏疽性脓皮病，另外2例为肉芽肿浅表型。腿部是最常见的发病部位。它常与其他皮肤部位同时出现。2例患者有嗜中性粒细胞性肺部受累，与皮肤溃疡同时发生。8例患者发现与内科疾病有关。组织学检查显示11例患者有血管炎。其中9例观察到白细胞破碎性血管炎。泼尼松和氯法齐明是最常使用的药物。无论治疗如何，坏疽性脓皮病的复发率为46%。我们的2例患者中，嗜中性粒细胞性肺病的发生迅速导致死亡
