Le Moing V, Eid Z, Ecobichon J L, Duval X, Longuet P, Elbim C, Brun-Vezinet F, Leport C, Vilde J L
Service des Maladies Infectieuses et Tropicales, Hôpital Bichat--Claude Bernard, Paris.
Ann Med Interne (Paris). 2001 Feb;152(1):11-4.
From March to July 1996, 61 patients with CD4<50/mm(3)began a therapy with protease inhibitors. Increase and maintenance of CD4>100/mm(3) was observed in 39/61 patients with a protective effect for occurrence of AIDS or death. This immunological response was correlated with the duration of the virological response. However, 38% of patients with long-term immunological response never had a undetectable viral load.
1996年3月至7月，61例CD4细胞计数<50/mm³的患者开始接受蛋白酶抑制剂治疗。在61例患者中有39例观察到CD4细胞计数增加并维持在>100/mm³，对艾滋病的发生或死亡具有保护作用。这种免疫反应与病毒学反应的持续时间相关。然而，38%具有长期免疫反应的患者病毒载量从未低于检测下限。
