Kling F, Colin J
Service d'ophtalmologie, CHU de Brest, 29 200 Brest.
J Fr Ophtalmol. 2001 Jan;24(1):7-12.
Authors report an unexpected association between PEX and ARMD. It was an additional result of a study, that analysed possible systemic symptoms of pseudoexfoliation material in visceral organs. They reviewed literature data for both, concerning epidemiology and physiopathogeny.
We conducted an age-and sex matched study of 142 patients in Brittany, 71 PEX and 71 controls, 31 men and 40 women in the 2 groups. The statistical study was performed with Epi Info 6.0 software using the X2 of Mantel-Haenszel Test.
Statistical positive relation was found between PEX and ARMD (p=0.02), both increasing with age.
Part of epidemiology seems to be similar in PEX and ARMD, especially environment role (particularly solar radiations), individual factors, and genetic predisposition. For the first time, in may 1999, a genetic localization of PEX was discovered on the chromosome II, and nearly of one loci of ARMD multiple localizations.
作者报告了假性剥脱综合征（PEX）与年龄相关性黄斑变性（ARMD）之间意外的关联。这是一项研究的额外结果，该研究分析了内脏器官中假性剥脱物质可能的全身症状。他们回顾了关于两者的流行病学和病理生理学的文献数据。
我们对布列塔尼的142名患者进行了年龄和性别匹配的研究，其中71例为PEX患者，71例为对照组，两组中男性31例，女性40例。使用Epi Info 6.0软件通过Mantel-Haenszel检验的X2进行统计学研究。
发现PEX与ARMD之间存在统计学上的正相关（p = 0.02），两者均随年龄增长而增加。
PEX和ARMD的部分流行病学似乎相似，特别是环境作用（尤其是太阳辐射）、个体因素和遗传易感性。1999年5月首次发现PEX在12号染色体上的基因定位，且与ARMD多个定位中的一个位点相近。
