Southern S. A., Herrington C. S.
Department of Pathology, University of Liverpool, Royal Liverpool University Hospital, Liverpool, England, United Kingdom.
Int J Gynecol Cancer. 2000 Jul;10(4):263-274. doi: 10.1046/j.1525-1438.2000.010004263.x.
Human papillomaviruses (HPVs) play a major role in neoplastic transformation of squamous epithelial cells. The viral genome is small in size and only encodes a limited number of proteins, so one of the major functions of the viral proteins is to modulate the function of key cellular proteins involved in cell cycle control and DNA replication. During this process important host cell cycle checkpoints are lost which may lead to the accumulation of genetic abnormalities and eventual malignant transformation. This review briefly describes the normal cell cycle and also the mechanisms by which HPVs interfere with cell cycle control both as part of their productive life cycle and in the process of neoplastic transformation.
人乳头瘤病毒（HPV）在鳞状上皮细胞的肿瘤转化中起主要作用。病毒基因组规模小，仅编码有限数量的蛋白质，因此病毒蛋白的主要功能之一是调节参与细胞周期控制和DNA复制的关键细胞蛋白的功能。在此过程中，重要的宿主细胞周期检查点丧失，这可能导致遗传异常的积累并最终发生恶性转化。本文综述简要描述了正常细胞周期以及HPV干扰细胞周期控制的机制，这些机制既是其生产性生命周期的一部分，也是肿瘤转化过程的一部分。
