Fujii Y, Tanaka H, Kobayashi N
Department of Anesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.
Otolaryngol Head Neck Surg. 2001 Mar;124(3):266-9. doi: 10.1067/mhn.2001.113140.
To evaluate the efficacy and safety of small doses of propofol, droperidol, and metoclopramide for the prevention of postoperative nausea and vomiting (PONV) after thyroidectomy.
Prospective, randomized, double-blinded study.
University-affiliated teaching hospital.
In a randomized, double-blinded study, 90 patients (75 females) received propofol 0.5 mg/kg, droperidol 20 microg/kg, or metoclopramide 0.2 mg/kg intravenously (n = 30 in each group) at the end of surgery. A standardized general anesthetic technique was used.
The incidence of PONV during the first 24 hours after anesthesia was recorded in 13%, 47%, and 50% of patients who had received propofol, droperidol, and metoclopramide, respectively (P < 0.05; overall Fisher exact probability test). No clinically important adverse events were observed in any of the groups.
Small dose (0.5 mg/kg) of propofol is more effective than droperidol or metoclopramide for the prevention of PONV after thyroidectomy.
评估小剂量丙泊酚、氟哌利多和甲氧氯普胺预防甲状腺切除术后恶心呕吐（PONV）的有效性和安全性。
前瞻性、随机、双盲研究。
大学附属医院。
在一项随机双盲研究中，90例患者（75例女性）在手术结束时静脉注射丙泊酚0.5mg/kg、氟哌利多20μg/kg或甲氧氯普胺0.2mg/kg（每组n = 30）。采用标准化全身麻醉技术。
记录到接受丙泊酚、氟哌利多和甲氧氯普胺的患者在麻醉后24小时内PONV的发生率分别为13%、47%和50%（P < 0.05；总体Fisher确切概率检验）。在任何一组中均未观察到具有临床意义的不良事件。
小剂量（0.5mg/kg）丙泊酚在预防甲状腺切除术后PONV方面比氟哌利多或甲氧氯普胺更有效。
