Kato J, Kuwabara Y, Mitani M, Shinoda N, Sato A, Toyama T, Mitsui A, Nishiwaki T, Moriyama S, Kudo J, Fujii Y
Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan.
Int J Cancer. 2001 Mar 20;95(2):92-5. doi: 10.1002/1097-0215(20010320)95:2<92::aid-ijc1016>3.0.co;2-9.
Survivin, a new member of the inhibitor-of-apoptosis (IAP) family, has been reported to be expressed in many cancers but not in differentiated normal tissue. Its expression in esophageal cancer, however, has not been reported. We investigated 51 esophageal cancers and their adjacent normal epithelial tissues for mRNA expression of survivin by RT-PCR. The survivin expression in esophageal cancer tissue was significantly higher than that in normal esophageal tissue (0.211 +/- 0.226 vs. 0.057 +/- 0.135, p < 0.0001). pN4 tumors had significantly higher survivin expression than the pN0-3 tumors (p = 0.0093). Fourteen patients with advanced esophageal cancer had received chemotherapy prior to surgery. The survivin expression in the cancer tissue in patients who achieved a partial response (PR) was significantly lower than that in patients with no change (NC) and in patients with progressive disease (PD; 0.099 +/- 0.134 vs. 0.320 +/- 0.222, p = 0.0434). The median survival for patients with high survivin expression (9.0 months) was less than that for patients with low survivin group expression (30.0 months, p = 0.0023). Survivin expression was one of the significant predictors of survival on univariate analysis (hazard ratio 2.471; 95% confidence interval 1.104-5.533). The results suggest that survivin expression may provide prognostic information in patients with esophageal cancer.
生存素是凋亡抑制蛋白（IAP）家族的一个新成员，据报道它在多种癌症中表达，但在分化的正常组织中不表达。然而，其在食管癌中的表达尚未见报道。我们通过逆转录聚合酶链反应（RT-PCR）研究了51例食管癌及其相邻正常上皮组织中生存素的mRNA表达。食管癌组织中生存素的表达明显高于正常食管组织（0.211±0.226对0.057±0.135，p<0.0001）。pN4期肿瘤的生存素表达明显高于pN0-3期肿瘤（p=0.0093）。14例晚期食管癌患者在手术前接受了化疗。达到部分缓解（PR）的患者癌组织中生存素的表达明显低于无变化（NC）和疾病进展（PD）的患者（0.099±0.134对0.320±0.222，p=0.0434）。生存素高表达患者的中位生存期（9.0个月）短于生存素低表达组患者（30.0个月，p=0.0023）。在单因素分析中，生存素表达是生存的重要预测指标之一（风险比2.471；95%置信区间1.104-5.533）。结果表明，生存素表达可能为食管癌患者提供预后信息。
