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The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses.

作者信息

Tan Qiang, Danishefsky Samuel J.

机构信息

Laboratory for Bioorganic Chemistry Sloan-Kettering Institute for Cancer Research 1275 York Avenue, New York, NY 10021 (USA).

出版信息

Angew Chem Int Ed Engl. 2001 Feb 16;40(4):647. doi: 10.1002/1521-3773(20010216)40:4<647::aid-anie6473>3.0.co;2-g.

Abstract
摘要

相似文献

1
The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses.CP - 263,114和CP - 225,917的合成:在构建C7时引人注目的远程立体控制 美国国立卫生研究院提供了资金支持(给S.J.D.的CA - 28824和HL - 25848号拨款,给斯隆 - 凯特琳研究所核心设施的CA - 08748号拨款)。Q.T.非常感谢美国国防部提供的博士后奖学金(美国陆军拨款号DAMD - 17 - 99 - 1 - 9373)。我们感谢辉瑞公司,特别是T. Kaneko博士和T.T. Dabrah博士进行的讨论以及提供来自发酵液的珍贵CP样品。我们感谢董方孟博士对这项工作的重大贡献。我们还感谢斯隆 - 凯特琳研究所核心设施的George Sukenick进行质谱分析以及在核磁共振光谱分析和高效液相色谱分析方面提供的帮助,感谢Sylvi Rusli进行质谱分析。
Angew Chem Int Ed Engl. 2001 Feb 16;40(4):647. doi: 10.1002/1521-3773(20010216)40:4<647::aid-anie6473>3.0.co;2-g.
2
The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses.CP - 263,114和CP - 225,917的合成:在构建C7时显著的远程立体控制 美国国立卫生研究院提供了资金支持(给S.J.D.的CA - 28824和HL - 25848号拨款,给斯隆 - 凯特琳研究所核心设施的CA - 08748号拨款)。Q.T.衷心感谢美国国防部授予的博士后奖学金(美国陆军拨款号DAMD - 17 - 99 - 1 - 9373)。我们感谢辉瑞公司,特别是T. Kaneko博士和T.T. Dabrah博士进行的讨论以及提供来自发酵液的宝贵CP样品。我们感谢董方孟博士对这项工作的重大贡献。我们还感谢斯隆 - 凯特琳研究所核心设施的George Sukenick进行质谱分析以及在核磁共振光谱分析和高效液相色谱分析方面提供的帮助,感谢Sylvi Rusli进行质谱分析。
Angew Chem Int Ed Engl. 2000 Dec 15;39(24):4509-4511.
8
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.海绵他汀类化合物:结构复杂的天然产物——第二部分:C(29 - 51)亚基的合成、片段组装以及(+)-海绵他汀2的最终合成 本研究得到了美国国立卫生研究院(国立癌症研究所)的资助,资助编号为CA - 70329;还给C.S.B.提供了美国国立卫生研究院博士后奖学金,给N.M.提供了日本学术振兴会奖学金,给V.A.D.提供了英国皇家学会富布赖特奖学金。我们还感谢第一制药株式会社和田边制药株式会社提供的资金支持。最后,我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士和Rakesh Kohli博士,他们分别在获取和解释高场核磁共振谱、X射线晶体结构以及质谱方面提供了帮助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):196-199.
9
The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.海绵他汀类化合物:结构复杂的天然产物——第一部分:通过构建高级ABCD片段对(+)-海绵他汀1进行形式合成 美国国立卫生研究院(国家癌症研究所)通过CA-70329号资助提供了资金支持,美国国立卫生研究院向A.M.B.和W.H.M.提供了博士后奖学金,日本学术振兴会向N.M.提供了奖学金,英国皇家学会富布赖特奖学金向V.A.D.提供了奖学金。我们还感谢第一制药株式会社和田边制药株式会社的资金支持。最后,我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士、Rakesh Kohli博士和John Dykins先生在获取和解释高场核磁共振光谱、X射线晶体结构和质谱方面提供的帮助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):191-195.

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