McConnell H D, Carr D H
Obstet Gynecol. 1975 May;45(5):547-52.
A cytogenetic study of 27 spontaneous abortions was carried out using the Q-banding technic. The specimens were selected for study in order to increase the likelihood of finding a chromosome anomaly. Sixteen of 27 specimens (59%) showed a chromosome abnormality. Trisomy was found in 9 of the specimens, and the chromosomes involved were Nos. 2, 8, 14, 16, and 22. There were 5 triploids and 2 tetraploids. Using marker chromosomes, it was found that the extra haploid set was paternally derived in two of the triploids which were favorable for study. The Q-banding technic provides accurate identification of the extra chromosomes in trisomy. When favorable markers are present in the parents, the source of the extra haploid set can be identified in triploid abortuses.
采用Q带技术对27例自然流产进行了细胞遗传学研究。选择这些标本进行研究是为了增加发现染色体异常的可能性。27例标本中有16例（59%）显示染色体异常。9例标本中发现三体，涉及的染色体为2号、8号、14号、16号和22号。有5个三倍体和2个四倍体。利用标记染色体发现，在两个有利于研究的三倍体中，额外的单倍体组来自父方。Q带技术可准确识别三体中的额外染色体。当父母中存在有利的标记时，可在三倍体流产儿中识别额外单倍体组的来源。
