Altes T A, Powers P L, Knight-Scott J, Rakes G, Platts-Mills T A, de Lange E E, Alford B A, Mugler J P, Brookeman J R
Department of Radiology, University of Virginia, Charlottesville, Virginia, USA.
J Magn Reson Imaging. 2001 Mar;13(3):378-84. doi: 10.1002/jmri.1054.
Asthma is a disease characterized by chronic inflammation and reversible obstruction of the small airways resulting in impaired pulmonary ventilation. Hyperpolarized 3He magnetic resonance (MR) lung imaging is a new technology that provides a detailed image of lung ventilation. Hyperpolarized 3He lung imaging was performed in 10 asthmatics and 10 healthy subjects. Seven asthmatics had ventilation defects distributed throughout the lungs compared with none of the normal subjects. These ventilation defects were more numerous and larger in the two symptomatic asthmatics who had abnormal spirometry. Ventilation defects studied over time demonstrated no change in appearance over 30-60 minutes. One asthmatic subject was studied twice in a three-week period and had ventilation defects which resolved and appeared in that time. This same subject was studied before and after bronchodilator therapy, and all ventilation defects resolved after therapy. Hyperpolarized 3He lung imaging can detect the small, reversible ventilation defects that characterize asthma. The ability to visualize lung ventilation offers a direct method of assessing asthmatics and their response to therapy.
哮喘是一种以慢性炎症和小气道可逆性阻塞为特征的疾病，可导致肺通气受损。超极化3He磁共振（MR）肺成像是一种能够提供肺通气详细图像的新技术。对10名哮喘患者和10名健康受试者进行了超极化3He肺成像检查。与正常受试者无一例出现通气缺陷相比，7名哮喘患者存在分布于全肺的通气缺陷。在肺功能测定异常的两名有症状哮喘患者中，这些通气缺陷更多且更大。对通气缺陷进行一段时间的研究发现，其在30 - 60分钟内外观无变化。一名哮喘受试者在三周内接受了两次检查，其通气缺陷在这段时间内消失并再次出现。对该受试者在支气管扩张剂治疗前后进行了检查，治疗后所有通气缺陷均消失。超极化3He肺成像能够检测出作为哮喘特征的微小、可逆性通气缺陷。可视化肺通气的能力为评估哮喘患者及其对治疗的反应提供了一种直接方法。
