Petersen M C, Palmer F B
University of Tennessee, The Health Science Center, College of Medicine, Memphis, Tennessee, USA.
Ment Retard Dev Disabil Res Rev. 2001;7(1):30-7. doi: 10.1002/1098-2779(200102)7:1<30::AID-MRDD1005>3.0.CO;2-2.
In recent years there have been a number of advances in understanding of predisposing and protective factors in the development of cerebral palsy in infants. Multiple gestation births, maternal infection, and maternal and fetal thrombophilic conditions all predispose to the development of CP in the infant. Opportunities for prevention of CP may develop from an improved understanding of these factors and their mechanisms of operation. Similar progress has been made in the evaluation of treatments for CP and the effects of these treatments on the individual's impairment, function, and disability. Selective posterior rhizotomy and Botulinum toxin A are now widely used in the treatment of spasticity. The challenge remains to determine how effectively these promising interventions can alter long-term function and quality of life outcomes in children and adults with CP.
近年来，在理解婴儿脑瘫发生的易感因素和保护因素方面取得了一些进展。多胎妊娠分娩、母体感染以及母体和胎儿的血栓形成倾向均易导致婴儿患脑瘫。对这些因素及其作用机制的深入了解可能为预防脑瘫带来契机。在脑瘫治疗评估以及这些治疗对个体损伤、功能和残疾的影响方面也取得了类似进展。选择性后根切断术和A型肉毒毒素目前广泛用于治疗痉挛。挑战依然存在，即要确定这些有前景的干预措施能在多大程度上有效改变脑瘫儿童和成人的长期功能及生活质量结局。
