Hidasi E, Soltész P
Debreceni Egyetem Orvos- és Egészségtudományi Centrum, Neurológiai Klinika.
Orv Hetil. 2001 Feb 18;142(7):335-9.
Clinical datas of 20 patients with severe Guillain-Barre syndrome were evaluated retrospectively. The diagnosis was established on the electrophysiological and histopathological examinations (electroneurography, electromyography, sural nerve and muscle biopsy) and the analysis of the cerebrospinal fluid. All of the patients were treated with plasma exchange and some of them with other immunomodulant therapies (intravenous immunoglobuline, steroid, cyclophosphamide), too. To judge the clinical state correctly we used the modified Rankin scale. The patient's follow up went on for maximum 4 years. The improvement was satisfactory in 7 cases (35%) and good in 6 patients (30%). The last 6 patients had pure motor neuropathy. Six patients (30%) remained in severe residual condition. All of them had long-term course of disease, serious sensory symptoms and predominantly axonal degeneration of the peripheral nerves. One patient had died. The plasma exchanges were well tolerated, without any serious adverse event. This therapy would be safe and effective help in Guillain-Barre syndrome.
对20例严重吉兰-巴雷综合征患者的临床资料进行回顾性评估。诊断基于电生理和组织病理学检查（神经电图、肌电图、腓肠神经和肌肉活检）以及脑脊液分析。所有患者均接受了血浆置换治疗，部分患者还接受了其他免疫调节治疗（静脉注射免疫球蛋白、类固醇、环磷酰胺）。为正确判断临床状态，我们使用了改良Rankin量表。对患者的随访最长持续4年。7例（35%）患者改善情况令人满意，6例（30%）患者改善情况良好。最后6例患者为纯运动性神经病。6例（30%）患者仍处于严重残留状态。他们均病程较长，有严重的感觉症状，且主要为周围神经轴索性变性。1例患者死亡。血浆置换耐受性良好，未发生任何严重不良事件。该疗法对吉兰-巴雷综合征将是安全有效的帮助。
