6-巯基嘌呤核苷在中性和碱性介质中的稳定性
The stability of 6-mercaptopurine riboside in neutral and basic medium.
作者信息
Jelińska A, Magdziarz M
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
出版信息
Acta Pol Pharm. 2000 Nov-Dec;57(6):407-9.
PMID:11243244
Abstract
The kinetics of hydrolysis of 6-mercaptopurine riboside (R-6-MP) was studied in aqueous solutions over the pH range of 6.11-12.13 at 353 K. The decomposition was investigated by HPLC method. At the pH range from 6.11 to 12.13 hydrolysis of 6-mercaptopurine riboside includes: spontaeous hydrolysis of non-protonated R-6-MP molecules mono- and di-anions R-6-MP molecules under the effect of water.
摘要
在353 K下，研究了6-巯基嘌呤核苷（R-6-MP）在pH值为6.11 - 12.13的水溶液中的水解动力学。采用高效液相色谱法研究其分解情况。在pH值6.11至12.13范围内，6-巯基嘌呤核苷的水解包括：未质子化的R-6-MP分子、R-6-MP分子的单阴离子和双阴离子在水的作用下的自发水解。
Zotero 插件