Kurt M, Bilge S S, Kukula O, Kesim Y, Celik S
Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Jpn J Pharmacol. 2001 Jan;85(1):92-4. doi: 10.1254/jjp.85.92.
The effects of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor and L-arginine, a NO precursor, were investigated on lidocaine-induced convulsions. In the first experiment, four groups of mice received physiological saline (0.9%), L-arginine (300 mg/kg, i.p.), L-NAME (100 mg/kg, i.p.) and diazepam (2 mg/kg), respectively. Thirty minutes after these injections, all mice received lidocaine (50 mg/kg, i.p.). In the second experiment, four groups of mice received similar treatment in the first experiment, and 30 min after these injections, all mice received a higher dose of lidocaine (80 mg/kg). L-NAME (100 mg/kg, i.p.) and diazepam (2 mg/kg) significantly decreased the incidence of lidocaine (50 mg/kg)-induced convulsions. In contrast, the L-arginine treatment increased the incidence of lidocaine (80 mg/kg, i.p.)-induced convulsions significantly. These results may suggest that NO is a proconvulsant mediator in lidocaine-induced convulsions.
研究了一氧化氮（NO）合酶抑制剂N-硝基-L-精氨酸甲酯（L-NAME）和NO前体L-精氨酸对利多卡因诱发惊厥的影响。在第一个实验中，四组小鼠分别接受生理盐水（0.9%）、L-精氨酸（300mg/kg，腹腔注射）、L-NAME（100mg/kg，腹腔注射）和地西泮（2mg/kg）。这些注射30分钟后，所有小鼠均接受利多卡因（50mg/kg，腹腔注射）。在第二个实验中，四组小鼠接受与第一个实验相似的处理，注射后30分钟，所有小鼠接受更高剂量的利多卡因（80mg/kg）。L-NAME（100mg/kg，腹腔注射）和地西泮（2mg/kg）显著降低了利多卡因（50mg/kg）诱发惊厥的发生率。相反，L-精氨酸处理显著增加了利多卡因（80mg/kg，腹腔注射）诱发惊厥的发生率。这些结果可能表明NO是利多卡因诱发惊厥中的一种惊厥促发介质。
