Roberts R L, Jenkins K T, Lawler T, Wegner F H, Newman J D
Unit on Developmental Neuroethology, University of Wisconsin, Madison, Wisconsin 53715, USA.
Horm Behav. 2001 Mar;39(2):106-12. doi: 10.1006/hbeh.2000.1639.
The influence of prolactin on parental responsiveness was investigated in eight unpaired, parentally inexperienced common marmosets (Callithrix jacchus; 6 female, 2 male). The marmosets were prescreened with infants (1-10 days of age) and required to exhibit short latency retrieval and infant carrying in at least three consecutive pretests as criterion for inclusion in this study. The marmosets were then administered the dopamine agonist bromocriptine (0.5 mg/0.5ml vehicle subcutaneously) and the vehicle alone (0.5 ml 10% ethanol solution) twice daily for 3 consecutive days in random order. Bromocriptine treatment reduced circulating prolactin to nondetectable levels. Bromocriptine treatment eliminated infant retrieval in four of the eight marmosets and was associated with significantly increased retrieval latencies and significantly reduced carrying durations in the four monkeys that continued to retrieve following bromocriptine treatment. When given the vehicle alone, the marmosets retrieved infants significantly faster than during pretests, suggesting a handling effect of the injection series. Bromocriptine treatments were associated with significantly increased movement during the tests. The results of this study indicate that prolactin and/or its regulatory neurotransmitters are involved in the control of the spontaneous display of parental responsiveness in common marmosets.
在8只未配对、无育儿经验的普通狨猴（Callithrix jacchus；6只雌性，2只雄性）中研究了催乳素对母性行为反应的影响。这些狨猴先用1 - 10日龄的幼崽进行预筛选，要求在至少连续三次预测试中表现出短潜伏期的幼崽找回行为和携带幼崽行为，以此作为纳入本研究的标准。然后，这些狨猴被随机给予多巴胺激动剂溴隐亭（0.5毫克/0.5毫升溶媒，皮下注射）和单独的溶媒（0.5毫升10%乙醇溶液），连续3天，每天2次。溴隐亭治疗使循环催乳素水平降至无法检测到的水平。溴隐亭治疗使8只狨猴中的4只消除了幼崽找回行为，并且在溴隐亭治疗后仍继续找回幼崽的4只猴子中，与找回潜伏期显著增加和携带时间显著缩短有关。当只给予溶媒时，狨猴找回幼崽的速度明显比预测试时快，这表明注射系列有操作效应。溴隐亭治疗与测试期间的活动显著增加有关。本研究结果表明，催乳素和/或其调节性神经递质参与了普通狨猴母性行为反应自发表现的控制。
