Ormerod L P, Horsfield N, Green R M
Chest Clinic, Blackburn Royal Infirmary, Blackburn, Lancs, BB2 3LR, UK.
J Infect. 2001 Jan;42(1):1-3. doi: 10.1053/jinf.2000.0773.
National tuberculosis treatment guidelines suggest a regimen of 2RZE/10RE for the treatment of isoniazid resistant organisms. A retrospective clinical study of all patients treated for non-MDR-TB isoniazid-resistant organisms was undertaken.
A continuous database of the patients treated between 1978-1999 inclusive was examined to determine the regimens used and the outcome of treatment for such patients.
Thirty-seven patients were identified. Eighteen had regimens of greater than 9 months, 19 had regimens of 9 months or less. No relapses occurred in those cases treated with a regimen of 2RZE/7RE during 12 months' minimum follow-up.
A regimen of 2RZE/7RE may be possible for the treatment of isoniazid-resistant organisms if given either under close supervision or as a formally supervised regimen. Larger clinical studies or a controlled clinical trial are needed to confirm these initial findings.
国家结核病治疗指南建议采用2RZE/10RE方案治疗耐异烟肼菌株。对所有接受非耐多药结核病耐异烟肼菌株治疗的患者进行了一项回顾性临床研究。
检查了一个包含1978年至1999年期间接受治疗患者的连续数据库，以确定所使用的治疗方案以及此类患者的治疗结果。
共确定了37例患者。18例采用了超过9个月的治疗方案，19例采用了9个月或更短时间的治疗方案。在至少12个月的随访期间，接受2RZE/7RE方案治疗的患者未出现复发。
如果在密切监督下或作为正式监督方案给予2RZE/7RE方案，可能可用于治疗耐异烟肼菌株。需要更大规模的临床研究或对照临床试验来证实这些初步发现。
