Mosimann W
Schweiz Med Wochenschr. 1975 Mar 1;105(9):257-63.
Antibiotic therapy during pregnancy is generally given to treat infectious diseases of the mother rather than of the fetus. Despite her altered physiology the pregnant woman poses few specific pharmacokinetic problems. The main concern is possible damage to the fetus, depending on its developmental stage at the time of administering the drug. Largely on an empirical basis, antibiotics which can be administered without hazard throughout pregnancy are distinguished from those which should be completely avoided during pregnancy and from others which must be omitted during certain phases of pregnancy. Similar considerations apply in the case of drugs used for the treatment of tuberculosis and mycoses.
孕期使用抗生素通常是为了治疗母亲而非胎儿的传染病。尽管孕妇的生理状态有所改变，但她几乎不存在特殊的药代动力学问题。主要担忧的是可能对胎儿造成损害，这取决于给药时胎儿的发育阶段。在很大程度上基于经验，可在整个孕期安全使用的抗生素与孕期应完全避免使用的抗生素以及在孕期某些阶段必须停用的抗生素区分开来。对于用于治疗结核病和真菌病的药物，也有类似的考虑。
