Hardy R R, Hayakawa K
Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, Pennsylvania 19111, USA.
Annu Rev Immunol. 2001;19:595-621. doi: 10.1146/annurev.immunol.19.1.595.
B cell development is a highly regulated process whereby functional peripheral subsets are produced from hematopoietic stem cells, in the fetal liver before birth and in the bone marrow afterward. Here we review progress in understanding some aspects of this process in the mouse bone marrow, focusing on delineation of the earliest stages of commitment, on pre-B cell receptor selection, and B cell tolerance during the immature-to-mature B cell transition. Then we note some of the distinctions in hematopoiesis and pre-B selection between fetal liver and adult bone marrow, drawing a connection from fetal development to B-1/CD5(+) B cells. Finally, focusing on CD5(+) cells, we consider the forces that influence the generation and maintenance of this distinctive peripheral B cell population, enriched for natural autoreactive specificities that are encoded by particular germline V(H)-V(L) combinations.
B细胞发育是一个高度受调控的过程，在此过程中，功能性外周亚群由造血干细胞产生，出生前在胎肝中，出生后在骨髓中。在这里，我们回顾了在理解小鼠骨髓中这一过程某些方面的进展，重点是对最早的定向阶段的描绘、前B细胞受体选择以及未成熟B细胞向成熟B细胞转变过程中的B细胞耐受性。然后我们指出了胎肝和成年骨髓在造血和前B细胞选择方面的一些差异，建立了从胎儿发育到B-1/CD5(+) B细胞的联系。最后，聚焦于CD5(+)细胞，我们考虑了影响这一独特外周B细胞群体产生和维持的因素，该群体富含由特定种系V(H)-V(L)组合编码的天然自身反应性特异性。
