Ban M, Kitajima Y
Department of Dermatology, Hashima City Hospital, Hashima, Japan.
Dermatology. 2001;202(1):31-4. doi: 10.1159/000051581.
Rudimentary polydactyly histologically reveals a marked neural proliferation in the dermis and a large number of Meissner corpuscles in the dermal papillae.
Our study was performed to determine whether this neural proliferation is related to Merkel cells.
Using an antibody to cytokeratin 20, we examined the number and distribution of Merkel cells in 5 cases of rudimentary polydactyly, including an immature case without Meissner corpuscles.
Only the case without Meissner corpuscles had a markedly large number of Merkel cells and some dermal Merkel cells.
The normal number of Merkel cells in the mature cases suggests that abundant Merkel cells may appear at first and disappear after the development of neural proliferation. Merkel cells may be associated with the generation of cutaneous nerve plexus and nerve endings in the upper dermis, and possibly with the development of Meissner corpuscles, at the early stage of rudimentary polydactyly.
残遗性多指畸形在组织学上显示真皮内有明显的神经增生，真皮乳头中有大量迈斯纳小体。
我们开展本研究以确定这种神经增生是否与默克尔细胞有关。
我们使用细胞角蛋白20抗体，检查了5例残遗性多指畸形中默克尔细胞的数量和分布，其中包括1例没有迈斯纳小体的未成熟病例。
只有没有迈斯纳小体的病例有大量明显的默克尔细胞和一些真皮内默克尔细胞。
成熟病例中默克尔细胞的正常数量表明，在神经增生出现之前可能首先出现大量默克尔细胞，之后消失。在残遗性多指畸形的早期阶段，默克尔细胞可能与真皮上层皮肤神经丛和神经末梢的生成有关，也可能与迈斯纳小体的发育有关。
