Ogino H, Ueda Y, Sugita T, Sakakibara Y, Matsuyama K, Matsubayashi K, Nomoto T
Department of Cardiovascular Surgery, Tenri Hospital, Tenri, Japan.
Kyobu Geka. 2001 Mar;54(3):175-80 discussion 180-3.
Surgical outcome for thoracic aortic aneurysms involving the distal arch via a left thoracotomy using retrograde cerebral perfusion combined with profound hypothermic circulatory arrest was reviewed. Twelve patients with a atherosclerotic aortic aneurysm between 1994 and 1997 were involved. A proximal aortic anastomosis was made by means of an open aortic technique. For the first four patients, oxygenated arterial blood from cardiopulmonary bypass was perfused retrogradely through a venous cannula positioned into the right atrium. In the last eight cases, venous blood provided by a low-flow perfusion of the lower half body via the femoral artery, which was still oxygen-saturated, was circulated passively in the brain in a retrograde fashion with the descending aorta clamped. Prosthetic replacement was done between the distal arch and the proximal descending aorta in 6 patients and from the distal arch to the entire descending thoracic aorta in 6 patients. The median duration of hypothermic circulatory arrest and continuous retrograde cerebral perfusion was 36 minutes and 33 minutes respectively. The overall outcome was satisfactory without early mortality--all patients survived, although an octogenarian died of respiratory failure 1 year postoperatively. Another octogenarian with a ruptured aneurysm developed delay of meaningful consciousness, and other two patients with a severely atherosclerotic aneurysm suffered permanent neurological dysfunction (stroke) presumably due to an embolic episode. The safe and simple combination of profound hypothermic circulatory arrest, retrograde cerebral perfusion, and open aortic anastomosis protects the brain adequately and produces satisfactory results in surgery for aortic aneurysms involving the distal arch through a left thoracotomy.
回顾了采用逆行脑灌注联合深度低温循环停止,经左胸切口治疗累及主动脉弓远端的胸主动脉瘤的手术结果。纳入了1994年至1997年间12例患有动脉粥样硬化性主动脉瘤的患者。采用开放主动脉技术进行近端主动脉吻合。对于前4例患者,体外循环的含氧动脉血通过置于右心房的静脉插管逆行灌注。在最后8例病例中,通过股动脉对下半身进行低流量灌注提供的静脉血(仍为氧饱和状态),在降主动脉夹闭的情况下以逆行方式被动地在大脑中循环。6例患者在主动脉弓远端与降主动脉近端之间进行了人工血管置换,6例患者从主动脉弓远端至整个胸降主动脉进行了置换。低温循环停止和持续逆行脑灌注的中位持续时间分别为36分钟和33分钟。总体结果令人满意,无早期死亡——所有患者均存活,尽管一名八旬老人术后1年死于呼吸衰竭。另一名患有动脉瘤破裂的八旬老人出现了意识恢复延迟,另外两名患有严重动脉粥样硬化性动脉瘤的患者可能由于栓塞事件而出现永久性神经功能障碍(中风)。深度低温循环停止、逆行脑灌注和开放主动脉吻合的安全简单组合能充分保护大脑,对于经左胸切口治疗累及主动脉弓远端的主动脉瘤手术可产生令人满意的结果。