初步报告：氟马西尼对ddY小鼠丙泊酚催眠剂量的影响

[Preliminary report: the effect of flumazenil on the hypnotic dose of propofol in ddY mice].

作者信息

Adachi Y, Watanabe K, Uchihashi Y, Higuchi H, Satoh T

机构信息

Department of Anesthesiology, National Defense Medical College, Tokorozawa 359-8513.

出版信息

Masui. 2001 Feb;50(2):164-7.

PMID:11244771

Abstract

The present investigation dealt with the effect of simultaneous administration of flumazenil on the hypnotic activity of propofol using a behavioral model of ddY mice. The mixed solution of propofol and flumazenil was administered intravenously into the mice tail vein and the achievement of hypnosis was defined as the loss of the righting reflex. Flumazenil 0.2 mg.kg-1 significantly decreased the required dose of propofol for hypnosis (8.43 +/- 0.46 mg.kg-1) compared to the control group (10.55 +/- 0.55 mg.kg-1). The mixture with a pH-3.9 acetate buffer solution did not change the hypnotic dose of propofol (10.88 +/- 0.62 mg.kg-1). The results suggest that flumazenil might potentiate the hypnotic activity of propofol in ddY mice.

摘要

本研究利用ddY小鼠行为模型探讨了同时给予氟马西尼对丙泊酚催眠活性的影响。将丙泊酚与氟马西尼的混合溶液经小鼠尾静脉静脉注射，将催眠的达成定义为翻正反射消失。与对照组（10.55±0.55mg·kg-1）相比，0.2mg·kg-1的氟马西尼显著降低了丙泊酚催眠所需剂量（8.43±0.46mg·kg-1）。与pH为3.9的醋酸盐缓冲溶液混合并未改变丙泊酚的催眠剂量（10.88±0.62mg·kg-1）。结果表明，氟马西尼可能增强丙泊酚对ddY小鼠的催眠活性。