Iwasaki F, Mimura M, Yamazaki Y, Hazama K, Sato Y, Namiki A
Department of Anesthesiology, Takikawa Municipal Hospital, Takikawa 073-0022.
Masui. 2001 Feb;50(2):168-70.
A 47-year-old female was scheduled for ulnar osteotomy under general anesthesia combined with brachial plexus block. She had a history of symptomatic epilepsy due to subarachnoid hemorrhage. Immediately after giving 100 mg bolus of propofol to the patient, she developed generalized convulsion similar to a grand mal. The seizure was suppressed by the administration of thiamylal. After that no further convulsive attack occurred. Although it has been known that propofol has anticonvulsive properties, there have been several reported cases of seizure following the administration of propofol. Further studies are needed to clarify the mechanism of seizure induced by propofol in the patients with epilepsy.
一名47岁女性计划在全身麻醉联合臂丛神经阻滞下进行尺骨截骨术。她有因蛛网膜下腔出血导致的症状性癫痫病史。在给患者静脉推注100毫克丙泊酚后，她立即出现了类似癫痫大发作的全身性惊厥。通过给予硫喷妥钠，惊厥得到了抑制。此后未再发生惊厥发作。尽管已知丙泊酚具有抗惊厥特性，但仍有几例关于丙泊酚给药后发生癫痫发作的报道。需要进一步研究以阐明丙泊酚在癫痫患者中诱发癫痫发作的机制。
