锝-99m 半胱氨酸乙酯全身闪烁扫描在检测肝细胞癌骨转移中的应用价值。
Utility of Tc-99m GSA whole-body scintigraphy in detecting bone metastases from hepatocellular carcinoma.
作者信息
Sueyoshi K, Narabayashi I, Aratani T, Doi K, Komori T, Ogura Y, Utsunomiya K, Shimidzu T
机构信息
Osaka Medical College, Department of Radiology, Takatuki-city, Japan.
出版信息
Clin Nucl Med. 2001 Mar;26(3):221-4. doi: 10.1097/00003072-200103000-00008.
Recent advances in the treatment of hepatocellular carcinoma (HCC) have prolonged patient survival. However, the number of patients with bone metastases identified during follow-up examinations has increased. Tc-99m Sn-N-pyridoxy-5-methyltryptophan (Tc-99m PMT) has been reported to accumulate at a high rate in HCC lesions and bone metastases. In the patient described here, whole-body scintigraphy showed accumulation of DTPA galactosyl human serum albumin (Tc-99m GSA) and Tc-99m PMT in bone metastases from HCC. The authors suggest that asialoglycoprotein receptors may be present in bone metastases from well-differentiated HCC. Tc-99m GSA whole-body imaging can be used to detect bone metastases from HCC and to evaluate hepatic reserve.
肝细胞癌（HCC）治疗方面的最新进展延长了患者的生存期。然而，随访检查中发现的骨转移患者数量有所增加。据报道，锝-99m N-吡哆醛-5-甲基色氨酸（Tc-99m PMT）在HCC病灶和骨转移中大量聚集。在此描述的患者中，全身闪烁显像显示二乙三胺五乙酸半乳糖基人血清白蛋白（Tc-99m GSA）和Tc-99m PMT在HCC骨转移灶中聚集。作者认为，去唾液酸糖蛋白受体可能存在于高分化HCC的骨转移灶中。Tc-99m GSA全身显像可用于检测HCC的骨转移并评估肝储备功能。
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