Dunn I F, Heese O, Black P M
Brain Tumor Research Center, Brigham and Women's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
J Neurooncol. 2000 Oct-Nov;50(1-2):121-37. doi: 10.1023/a:1006436624862.
It has become well accepted that solid tumors must create a vascular system for nutrient delivery and waste removal in order to grow appreciably. This process, angiogenesis, is critical to the progression of gliomas, with vascular changes accompanying the advancement of these tumors. The cascade of events in this process of blood vessel formation involves a complex interplay between tumor cells, endothelial cells, and their surrounding basement membranes in which enzymatic degradation of surrounding ground substance and subsequent endothelial cell migration, proliferation, and tube formation occurs. It is likely that a host of growth factors is responsible for mediating these key events. To date, a role for Vascular Endothelial Growth Factor (VEGF) in glioma angiogenesis has been convincingly demonstrated. This review explores the contribution of other growth factors--Fibroblast Growth Factors (FGFs), Platelet-Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF), and Transforming Growth Factors (TGFs)--to glioma angiogenesis. These growth factors may influence glioma angiogenesis by directly stimulating endothelial cell proliferation, by mediating the expression of key proteases on endothelial cells necessary for angiogenesis, or by regulating the expression of VEGF and of each other.
实体瘤必须建立一个血管系统用于营养输送和废物清除，以便显著生长，这一点已被广泛接受。这个过程，即血管生成，对胶质瘤的进展至关重要，随着这些肿瘤的发展会伴随血管变化。血管形成过程中的一系列事件涉及肿瘤细胞、内皮细胞及其周围基底膜之间的复杂相互作用，其中会发生周围基质的酶促降解以及随后的内皮细胞迁移、增殖和管腔形成。可能有许多生长因子负责介导这些关键事件。迄今为止，血管内皮生长因子（VEGF）在胶质瘤血管生成中的作用已得到令人信服的证明。本综述探讨了其他生长因子——成纤维细胞生长因子（FGFs）、血小板衍生生长因子（PDGF）、表皮生长因子（EGF）和转化生长因子（TGFs）——对胶质瘤血管生成的贡献。这些生长因子可能通过直接刺激内皮细胞增殖、介导血管生成所需的内皮细胞上关键蛋白酶的表达或调节VEGF的表达以及彼此之间的表达来影响胶质瘤血管生成。
