Kolben M, Mandoki E, Ulm K, Freitag K
Frauenklinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Germany.
Eur J Clin Microbiol Infect Dis. 2001 Jan;20(1):40-2. doi: 10.1007/s100960000365.
A prospective, randomized study was performed in order to evaluate the effect of cefotiam in the prevention of postoperative infectious morbidity in patients undergoing low-risk elective cesarean section. A total of 146 patients were randomly assigned to receive either intraoperative single-shot prophylaxis with 2 g cefotiam (study group, n =76) or no prophylaxis (control group, n=70). Due to a higher rate of urinary tract infections, the incidence of infectious morbidity after cefotiam prophylaxis was higher in the study group than in the control group (16% vs. 9%, P=0.1). Postoperative infectious morbidity following low-risk elective cesarean section cannot be reduced by intraoperative cefotiam prophylaxis.
为了评估头孢替安在预防低风险择期剖宫产患者术后感染性并发症方面的效果，开展了一项前瞻性随机研究。总共146例患者被随机分配，分别接受术中单次预防性注射2g头孢替安（研究组，n = 76）或不进行预防（对照组，n = 70）。由于尿路感染发生率较高，头孢替安预防后研究组的感染性并发症发生率高于对照组（16%对9%，P = 0.1）。术中使用头孢替安预防不能降低低风险择期剖宫产术后的感染性并发症发生率。
