Clark L, Iversen S D, Goodwin G M
University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK.
J Affect Disord. 2001 Mar;63(1-3):179-87. doi: 10.1016/s0165-0327(00)00183-x.
significant frontal cortex dysfunction. It is hypothesised that performance on frontal lobe tasks may be sensitive to induced fluctuations in mood state in non-clinical samples.
Subjects performed one of two neuropsychological tasks immediately subsequent to a musical mood induction procedure designed to induce either elation or depression. Mood was assessed using self-report measures. Salivary cortisol levels were also measured in an attempt to objectively validate mood induction effects. The tasks used were verbal fluency and Damasio's Gambling Game. Two groups of subjects were recruited: a group with previous (subclinical) hypomanic experience (n=23) and a control group without previous hypomanic experience (n=23).
The positive and negative mood inductions produced robust and contrasting effects on self-reported mood, but had no significant differential effects on salivary cortisol levels and neuropsychological performance.
The findings are restricted by the absence of a neutral mood control condition.
Salivary cortisol recording does not provide a simple and reliable method of validating psychological mood induction. Performance on frontal lobe tests appears to be insensitive to normal mood fluctuations, which supports the argument that the deficits in mood disorder patient groups may instead reflect core disturbances of neurobiological processes.
显著的额叶皮质功能障碍。据推测，在非临床样本中，额叶任务的表现可能对情绪状态的诱发波动敏感。
在一个旨在诱发兴高采烈或抑郁情绪的音乐情绪诱导程序之后，受试者立即执行两项神经心理学任务之一。使用自我报告测量法评估情绪。还测量唾液皮质醇水平，以试图客观验证情绪诱导效果。所使用的任务是言语流畅性任务和达马西奥的赌博游戏。招募了两组受试者：一组有既往（亚临床）轻躁狂经历（n = 23），另一组为无既往轻躁狂经历的对照组（n = 23）。
积极和消极情绪诱导对自我报告的情绪产生了强烈且相反的影响，但对唾液皮质醇水平和神经心理学表现没有显著的差异影响。
由于缺乏中性情绪对照条件，研究结果受到限制。
唾液皮质醇记录不能提供一种简单可靠的方法来验证心理情绪诱导。额叶测试的表现似乎对正常情绪波动不敏感，这支持了这样一种观点，即情绪障碍患者组的缺陷可能反而反映了神经生物学过程的核心紊乱。
