Mahieu L M, Buitenweg N, Beutels P, De Dooy J J
Departments of Paediatrics, Division of Neonatology, University Hospital of Antwerp, Belgium.
J Hosp Infect. 2001 Mar;47(3):223-9. doi: 10.1053/jhin.2000.0852.
A comparative retrospective cohort study was performed to evaluate the influence of hospital-acquired infection (HAI) in neonates on additional charges and hospital stay. Neonates admitted between October 1993 and discharged alive before December 1995 at the neonatal intensive care unit of a university hospital were studied. Of 515 neonates, 69 (13%) had one or more HAI; 45 (20 with proven HAI, 25 with suspected HAI) were matched to 45 controls. After matching for gestational age, surgery, artificial ventilation and patent ductus arteriosus, central vascular catheter utilization was the only factor significantly associated with HAI. Charges were obtained from hospital discharge abstracts and the duration of hospitalization from patients' files. The mean additional length of hospital stay in neonates with HAI was 24 days (54 days vs. 30 days, P= 0.002) but did not differ significantly in patients with proven or suspected HAI (67 days vs. 51 days, P> 0.05). The mean extra charges for patients with a HAI were 11 750 EURO (9635 pounds). Accommodation accounted for 72%, fees for 22%, pharmaceuticals for 5% and ancillary items for 1% of these extra charges. The mean charges per day were similar for controls [443 EURO (363 pounds)] and HAI patients [453 EURO (372 pounds)]. Overall charges and charges per day were similar for neonates with proven and suspected HAI.
开展了一项比较性回顾性队列研究，以评估新生儿医院获得性感染（HAI）对额外费用和住院时间的影响。研究对象为1993年10月至1995年12月期间在某大学医院新生儿重症监护病房住院且存活出院的新生儿。在515例新生儿中，69例（13%）发生了一次或多次HAI；45例（20例确诊HAI，25例疑似HAI）与45例对照进行匹配。在对胎龄、手术、人工通气和动脉导管未闭进行匹配后，中心血管导管的使用是与HAI显著相关的唯一因素。费用从医院出院摘要中获取，住院时间从患者病历中获取。发生HAI的新生儿平均额外住院时间为24天（54天对30天，P = 0.002），但确诊或疑似HAI的患者之间无显著差异（67天对51天，P>0.05）。发生HAI的患者平均额外费用为11750欧元（9635英镑）。这些额外费用中，住宿费占72%，诊疗费占22%，药品费占5%，辅助项目费占1%。对照组[443欧元（363英镑）]和发生HAI的患者[453欧元（372英镑）]的日均费用相似。确诊和疑似HAI的新生儿的总费用和日均费用相似。
