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Ann Rheum Dis. 2001 Apr;60(4):305-9. doi: 10.1136/ard.60.4.305.
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[Regenerative potential of human adult precursor cells: cell therapy--an option for treating cartilage defects?].[人类成体前体细胞的再生潜力：细胞治疗——治疗软骨缺损的一种选择？]
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Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads.骨形态发生蛋白（BMP）-2可增强包埋于藻酸盐珠中的软骨细胞中II型胶原蛋白和聚集蛋白聚糖的表达。
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J Bone Miner Res. 2004 Aug;19(8):1308-19. doi: 10.1359/JBMR.040322. Epub 2004 Mar 29.

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Extremely low frequency-electromagnetic fields promote chondrogenic differentiation of adipose-derived mesenchymal stem cells through a conventional genetic program.极低频电磁场通过传统遗传程序促进脂肪来源间充质干细胞的软骨形成分化。
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BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis.BMP-2 基因编辑的人骨髓间充质干细胞通过抑制白细胞介素-34 减轻胶原诱导性关节炎的软骨退变。
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The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis.基于干细胞疗法对类风湿关节炎免疫反应的影响
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Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy.外泌体与干细胞在退行性疾病诊断与治疗中的应用
Cell Transplant. 2018 Mar;27(3):349-363. doi: 10.1177/0963689717723636. Epub 2018 Apr 25.
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Peripheral blood derived mononuclear cells enhance the migration and chondrogenic differentiation of multipotent mesenchymal stromal cells.外周血来源的单核细胞可增强多能间充质基质细胞的迁移和软骨分化。
Stem Cells Int. 2015;2015:323454. doi: 10.1155/2015/323454. Epub 2015 Jan 12.
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Expansion and preservation of multipotentiality of rabbit bone-marrow derived mesenchymal stem cells in dextran-based microcarrier spin culture.葡聚糖基微载体旋转培养扩增和维持兔骨髓间充质干细胞多能性。
J Mater Sci Mater Med. 2011 May;22(5):1343-56. doi: 10.1007/s10856-011-4294-7. Epub 2011 Apr 2.
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Mesenchymal stem cells: from biology to clinical use.间充质干细胞：从生物学到临床应用
Blood Transfus. 2007 Jul;5(3):120-9. doi: 10.2450/2007.0029-07.
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Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets.调节炎性骨溶解的机制：对治疗靶点的见解综述
Pathol Res Pract. 2008;204(10):695-706. doi: 10.1016/j.prp.2008.07.002. Epub 2008 Aug 30.

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Transcriptional control by the TGF-beta/Smad signaling system.转化生长因子-β/ Smad信号系统的转录调控
EMBO J. 2000 Apr 17;19(8):1745-54. doi: 10.1093/emboj/19.8.1745.
2
Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy.工程化多能间充质细胞在再生骨中整合并分化：一种新型细胞介导的基因治疗。
J Gene Med. 1999 Mar-Apr;1(2):121-33. doi: 10.1002/(SICI)1521-2254(199903/04)1:2<121::AID-JGM26>3.0.CO;2-J.
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Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow.人骨髓贴壁细胞培养中再生干细胞的快速扩增。
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3213-8. doi: 10.1073/pnas.97.7.3213.
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Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium.
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Translating stem and progenitor cell biology to the clinic: barriers and opportunities.将干细胞与祖细胞生物学应用于临床：障碍与机遇
Science. 2000 Feb 25;287(5457):1442-6. doi: 10.1126/science.287.5457.1442.
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Differential effects of interleukin-1 on hyaluronan and proteoglycan metabolism in two compartments of the matrix formed by articular chondrocytes maintained in alginate.白细胞介素-1对由藻酸盐中培养的关节软骨细胞形成的基质两个部分中透明质酸和蛋白聚糖代谢的不同影响。
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7
The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis.活化T细胞核因子（NFAT）转录因子NFATp（NFATc2）是软骨形成的抑制因子。
J Exp Med. 2000 Jan 3;191(1):9-22. doi: 10.1084/jem.191.1.9.
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Chondroprogenitor cells of synovial tissue.
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Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections.关节内注射转化生长因子-β导致小鼠膝关节出现骨关节炎样改变。
Osteoarthritis Cartilage. 2000 Jan;8(1):25-33. doi: 10.1053/joca.1999.0267.
10
In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector.使用骨形态发生蛋白2腺病毒载体的体内软骨内骨形成。
Hum Gene Ther. 1999 Sep 1;10(13):2245-53. doi: 10.1089/10430349950017220.

Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis.

作者信息

Jorgensen C, Noel D, Apparailly F, Sany J

机构信息

Service d'Immuno-Rhumatologie, Hôpital Lapeyronie, 371 avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France.

出版信息

Ann Rheum Dis. 2001 Apr;60(4):305-9. doi: 10.1136/ard.60.4.305.

DOI:10.1136/ard.60.4.305
PMID:11247853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1753607/
Abstract
摘要