胶原诱导性关节炎大鼠前交叉韧带的拉伸特性
Tensile properties of rat anterior cruciate ligament in collagen induced arthritis.
作者信息
Nawata K, Enokida M, Yamasaki D, Minamizaki T, Hagino H, Morio Y, Teshima R
机构信息
Department of Orthopaedic Surgery, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8504 Japan.
出版信息
Ann Rheum Dis. 2001 Apr;60(4):395-8. doi: 10.1136/ard.60.4.395.
OBJECTIVES
To investigate the effects of collagen induced arthritis (CIA) on the tensile properties of rat anterior cruciate ligament (ACL).
METHODS
The tensile strength, bone mineral density (BMD), and histology of ACL units from rats with CIA were investigated.
RESULTS
The tensile strength of the ACL unit was significantly lower in the rats with CIA at 10 weeks after immunisation (ultimate failure load, 74.9% of the control; stiffness, 62.0% of the control). The major mode of failure was femoral avulsion, and the BMD was significantly lower in the rats with CIA. A histological examination of the ligament insertion in rats with CIA showed resorption of the cortical bone beneath the ACL insertion and an enlarged mineralised fibrocartilage zone.
CONCLUSIONS
These findings indicate that the decrease in tensile strength of ACL units correlated with histological changes in the ligament-bone attachment, such as bone resorption beneath the ligament insertion site and an enlargement of the mineralised fibrocartilage zone.
目的
研究胶原诱导性关节炎（CIA）对大鼠前交叉韧带（ACL）拉伸性能的影响。
方法
对患有CIA的大鼠的ACL单元的拉伸强度、骨密度（BMD）和组织学进行了研究。
结果
免疫后10周，患有CIA的大鼠的ACL单元的拉伸强度显著降低（极限破坏载荷，为对照组的74.9%；刚度，为对照组的62.0%）。主要的破坏模式是股骨撕脱，且患有CIA的大鼠的骨密度显著降低。对患有CIA的大鼠的韧带附着点进行组织学检查，结果显示ACL附着点下方的皮质骨吸收，矿化纤维软骨区扩大。
结论
这些发现表明，ACL单元拉伸强度的降低与韧带-骨附着处的组织学变化相关，如韧带插入部位下方的骨吸收和矿化纤维软骨区的扩大。
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