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Closing down on glyphosate inhibition--with a new structure for drug discovery.

作者信息

Alibhai M F, Stallings W C

机构信息

Monsanto Corporation, Roundup Ready Technology, 700 Chesterfield Parkway North, Chesterfield, MO 63017, USA.

出版信息

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):2944-6. doi: 10.1073/pnas.061025898.

DOI:10.1073/pnas.061025898
PMID:11248008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC33334/
Abstract
摘要

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2
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3
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Solid-state NMR determination of intra- and intermolecular 31P-13C distances for shikimate 3-phosphate and [1-13C]glyphosate bound to enolpyruvylshikimate-3-phosphate synthase.固态核磁共振法测定与烯醇丙酮酸莽草酸-3-磷酸合酶结合的莽草酸-3-磷酸和[1-¹³C]草甘膦的分子内和分子间³¹P-¹³C距离。
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本文引用的文献

1
The Site of the Inhibition of the Shikimate Pathway by Glyphosate: II. INTERFERENCE OF GLYPHOSATE WITH CHORISMATE FORMATION IN VIVO AND IN VITRO.草甘膦对莽草酸途径抑制作用的作用部位：二、草甘膦对体内和体外分支酸形成的干扰。
Plant Physiol. 1980 Nov;66(5):830-4. doi: 10.1104/pp.66.5.830.
2
Import of a precursor protein into chloroplasts is inhibited by the herbicide glyphosate.前体蛋白向叶绿体的输入被除草剂草甘膦所抑制。
EMBO J. 1988 May;7(5):1299-305. doi: 10.1002/j.1460-2075.1988.tb02944.x.
3
Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.草甘膦靶标5-烯醇丙酮酰莽草酸-3-磷酸合酶的结构与拓扑对称性：一种独特的蛋白质折叠。
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5046-50. doi: 10.1073/pnas.88.11.5046.
4
Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.除草剂草甘膦与其靶标酶5-烯醇丙酮酰莽草酸-3-磷酸合酶相互作用的原子细节。
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1376-80. doi: 10.1073/pnas.98.4.1376.
5
Comparative X-ray analysis of the un-liganded fosfomycin-target murA.未结合磷霉素的靶标murA的X射线对比分析
Proteins. 2000 Aug 1;40(2):290-8. doi: 10.1002/(sici)1097-0134(20000801)40:2<290::aid-prot90>3.0.co;2-0.
6
Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA.荧光探针8-苯胺基-1-萘磺酸（ANS）与抗生素靶点MurA相互作用的结构基础。
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6345-9. doi: 10.1073/pnas.120120397.
7
Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA.包含第115位残基的环在细菌细胞壁生物合成酶MurA的诱导契合机制中的作用。
Biochemistry. 2000 Mar 7;39(9):2164-73. doi: 10.1021/bi991091j.
8
Substrate and inhibitor-induced conformational changes in the structurally related enzymes UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS).结构相关酶UDP-N-乙酰葡糖胺烯醇丙酮酸转移酶（MurA）和5-烯醇丙酮酸莽草酸-3-磷酸合酶（EPSPS）中底物和抑制剂诱导的构象变化。
Biochemistry. 1999 Jul 13;38(28):8864-78. doi: 10.1021/bi990412o.
9
Evidence for the shikimate pathway in apicomplexan parasites.顶复门寄生虫中莽草酸途径的证据。
Nature. 1998 Jun 25;393(6687):801-5. doi: 10.1038/31723.
10
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin.UDP-N-乙酰葡糖胺烯醇丙酮酸转移酶的结构，该酶是细菌肽聚糖合成所必需的一种酶，与底物UDP-N-乙酰葡糖胺和药物磷霉素形成复合物。
Structure. 1996 Dec 15;4(12):1465-74. doi: 10.1016/s0969-2126(96)00153-0.