睾丸FasL由精子细胞表达。
Testicular FasL is expressed by sperm cells.
作者信息
D'Alessio A, Riccioli A, Lauretti P, Padula F, Muciaccia B, De Cesaris P, Filippini A, Nagata S, Ziparo E
机构信息
Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Histology and Medical Embryology, University of Rome "La Sapienza," 00161 Rome, Italy.
出版信息
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3316-21. doi: 10.1073/pnas.051566098. Epub 2001 Feb 27.
Abstract
The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune-privileged status in the testis by eliminating infiltrating inflammatory Fas-bearing leukocytes. Our results demonstrate that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that FasL transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa. These findings point to a significant role of the Fas system in the biology of mammalian reproduction.
摘要
在啮齿动物中，睾丸是Fas配体（FasL）mRNA的主要来源；人们普遍认为，这种在相邻的支持细胞上表达的分子，通过清除浸润的携带Fas的炎性白细胞，赋予睾丸免疫特权地位。我们的结果表明，将FasL的睾丸表达归因于支持细胞是错误的，FasL转录实际上发生在减数分裂和减数分裂后的生殖细胞中，而该蛋白仅在成熟精子上显示。这些发现表明Fas系统在哺乳动物生殖生物学中具有重要作用。
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