Intrinsic asthma associated with diabetes mellitus; abnormal vascular response and glucose tolerance tests.

Patients manifesting intrinsic idiopathic rhinitis and/or asthma in association with diabetes or aspirin intolerance were studied. Various metabolites (sugars and L-histidine) and chemical (aspirin, insulin and glucagon) challenges were studied using the parameter of the induced sequential vascular response. A standard oral glucose tolerance test was also correlated. The results indicated similar as well as divergent ab- nc. nalities of responses to the various carbohydrates, insulin, glucagon, L-histidine and aspirin challenges. This permitted a separation of some patients with idiopathic rhinitis and/or asthma into those associated with diabetes and those with tolerance to aspirin.