deSa D J
Arch Dis Child. 1975 Jan;50(1):45-50. doi: 10.1136/adc.50.1.45.
A review of the histology of 332 ovaries from stillbirths and neonatal deaths within the first 28 days of life showed that follicular cysts, lined by granulosa epithelium and having a diameter greater than 1 mm on a microscopical section, were present in 113 infants. In 48 cases multiple cysts were present, while in 65 only a single cyst satisfying the criteria was found. There was an excess number of infants of low birthweight score among those with multiple cysts and the results were highly significant. Cysts, whether single or multiple in distribution, were commoner with increasing gestation, and possibly occurred more commonly in the infants of diabetic mothers and in infants where pregnancy had been complicated by rhesus isoimmunization. The nature of the changes seen in the granulosa lining and theca internal layer surrounding the cysts suggested that these cysts were not some degenerative phenomenon but occured in response to stimulation. It is suggested that homologous changes may occur in the testis of the dysmature male. The possible significance of these findings with regard to hormonal imbalance in the growth-retarded infant is considered, and the need for closer attention to endocrine function in these infants stressed.
对332例死产儿及出生后28天内新生儿死亡的卵巢进行组织学检查，结果显示，在113例婴儿的卵巢中发现有滤泡囊肿，显微镜下可见囊肿内衬颗粒上皮，直径大于1mm。其中48例为多发性囊肿，65例仅发现1个符合标准的囊肿。多发性囊肿患儿中低体重评分婴儿数量过多，结果具有高度显著性。囊肿无论单发还是多发，均随孕周增加而更常见，且可能在糖尿病母亲的婴儿以及因恒河猴血型免疫而使妊娠复杂化的婴儿中更常见。囊肿周围颗粒层内衬及卵泡内膜层的变化性质表明，这些囊肿并非某种退行性现象，而是对刺激的反应。有人提出，在发育不成熟的男性睾丸中可能会出现类似变化。文中考虑了这些发现对于生长发育迟缓婴儿激素失衡的可能意义，并强调需要更加密切关注这些婴儿的内分泌功能。
