Goldberg J
Robert Wood Johnson Medical School, Division of Hematology & Oncology, Cooper Health System, UMDNJ School, 3 Cooper Plaza, Camden, NJ 08103, USA.
Curr Opin Mol Ther. 2000 Apr;2(2):211-5.
Thrombopoietin is a protein factor that promotes growth and platelet production and can be used to avert thrombocytopenia, which can cause uncontrolled bleeding in cancer patients undergoing chemotherapy. Genentech, having cloned the gene encoding thrombopoietin, are developing a recombinant protein technology in collaboration with Pharmacia & Upjohn for the potential treatment of thrombocytopenia in chemotherapy patients [274038]. The technology entered phase II/III clinical trials in 1998 and these were ongoing as of February 2000 [355591].
血小板生成素是一种促进生长和血小板生成的蛋白质因子，可用于避免血小板减少症，血小板减少症会导致接受化疗的癌症患者出现无法控制的出血。基因泰克公司已克隆出编码血小板生成素的基因，正在与法玛西亚普强公司合作开发一种重组蛋白技术，用于潜在治疗化疗患者的血小板减少症[274038]。该技术于1998年进入II/III期临床试验，截至2000年2月这些试验仍在进行[355591]。
