Schwarzenberger P, Byrne P, Kolls J K
Louisiana State University Medical Center, Department of Medicine, Section Hematology/Oncology, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
Curr Opin Mol Ther. 1999 Feb;1(1):104-11.
Malignant mesothelioma (MM) is a tumor of the pleura with an etiology that has been strongly linked to previous asbestos exposure. It is an almost universally fatal disease, regardless of tumor stage at the time of diagnosis. Current treatment modalities include surgery, chemotherapy and radiation therapy, although in some clinical trials none of these modalities have proven to be superior to no treatment at all. Knowledge of the tumor biology and immunology of this disease is insufficient, although several studies suggest feasibility and success for immunotherapeutic strategies. In this article, we review previous work and describe novel therapeutic approaches utilizing biological response modification for MM.
恶性间皮瘤（MM）是一种胸膜肿瘤，其病因与既往石棉暴露密切相关。它几乎是一种普遍致命的疾病，无论诊断时的肿瘤分期如何。目前的治疗方式包括手术、化疗和放疗，尽管在一些临床试验中，这些方式均未被证明优于不进行任何治疗。尽管多项研究表明免疫治疗策略具有可行性和成功性，但对该疾病的肿瘤生物学和免疫学的了解仍不足。在本文中，我们回顾了以往的研究工作，并描述了利用生物反应调节剂治疗MM的新方法。
