Brook I
Georgetown University, 4431 Albemarle Street, Washington, DC 20016, USA.
Int J Pediatr Otorhinolaryngol. 2001 Apr 6;58(1):27-36. doi: 10.1016/s0165-5876(00)00457-2.
Sinusitis is a major cause of illness in the USA, and represents a substantial economic burden. Treatment of this condition usually involves antibiotics and, where there is a strong suspicion of bacterial etiology, has a high rate of success. Accurate diagnosis depends upon clinical assessment, but only four specific symptoms have been shown to be independent predictors of sinusitis. Other diagnostic approaches such as analysis of a microbiological sample must be considered in cases failing initial treatment. The main factors in choosing antibiotic therapy are the likely infecting pathogens, bacterial antibiotic resistance and antibiotics' pharmacological profiles. Accurate diagnosis and careful consideration when choosing therapy for sinusitis will optimise the chances of achieving an early cure.
鼻窦炎是美国疾病的主要成因之一，且带来了巨大的经济负担。这种病症的治疗通常涉及使用抗生素，并且在高度怀疑为细菌病因的情况下，治疗成功率较高。准确的诊断依赖于临床评估，但只有四种特定症状被证明是鼻窦炎的独立预测指标。对于初始治疗失败的病例，必须考虑其他诊断方法，如微生物样本分析。选择抗生素治疗的主要因素包括可能感染的病原体、细菌对抗生素的耐药性以及抗生素的药理学特性。准确诊断并在为鼻窦炎选择治疗方法时仔细考量，将优化实现早期治愈的几率。
