Woodcock C L, Dimitrov S
Biology Department, University of Massachusetts, Amherst 01003, USA.
Curr Opin Genet Dev. 2001 Apr;11(2):130-5. doi: 10.1016/s0959-437x(00)00169-6.
The linear array of nucleosomes that comprises the primary structure of chromatin is folded and condensed to varying degrees in nuclei and chromosomes forming 'higher order structures'. We discuss the recent findings from novel experimental approaches that have yielded significant new information on the different hierarchical levels of chromatin folding and their functional significance.
构成染色质一级结构的核小体线性阵列在细胞核和染色体中会以不同程度折叠和浓缩，形成“高阶结构”。我们讨论了来自新颖实验方法的最新发现，这些发现为染色质折叠的不同层次及其功能意义带来了重要的新信息。
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