脾酪氨酸激酶（Syk）：乳腺癌领域的新角色。
Syk: a new player in the field of breast cancer.
作者信息
Stewart Z A, Pietenpol J A
机构信息
Department of Biochemistry, Center in Molecular Toxicology, and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
Breast Cancer Res. 2001;3(1):5-7. doi: 10.1186/bcr261. Epub 2000 Nov 2.
Breast tumor development and progression are thought to occur through a complex, multistep process, including oncogene activation (eg HER2/neu) and mutation or loss of tumor suppressor genes (eg p53). Determining the function of genetic alterations in breast carcinoma tumorigenesis and metastasis has been the focus of intensive research efforts for several decades. One group of proteins that play a critical role in breast cancer cell signaling pathways are tyrosine kinases. Overexpression of the tyrosine kinase HER2/neu is observed in many human breast cancers and is positively correlated with enhanced tumorigenesis. Recently, another tyrosine kinase, Syk, has been implicated as an important inhibitor of breast cancer cell growth and metastasis. This recent finding was unexpected, since Syk function has been predominantly linked to hematopoietic cell signaling, and is discussed further in this commentary.
乳腺肿瘤的发生和发展被认为是一个复杂的多步骤过程，包括癌基因激活（如HER2/neu）以及肿瘤抑制基因的突变或缺失（如p53）。几十年来，确定基因改变在乳腺癌发生和转移中的作用一直是深入研究的重点。在乳腺癌细胞信号通路中起关键作用的一类蛋白质是酪氨酸激酶。在许多人类乳腺癌中都观察到酪氨酸激酶HER2/neu的过表达，并且与肿瘤发生增强呈正相关。最近，另一种酪氨酸激酶Syk被认为是乳腺癌细胞生长和转移的重要抑制剂。这一最新发现出人意料，因为Syk的功能主要与造血细胞信号传导有关，本评论将对此进行进一步讨论。
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